AFFIRM

About AFFIRM

about-affirmThere is growing international consensus that a task sharing approach is required to narrow the treatment gap for mental disorders in low and middle-income countries (LMIC). This means essentially that general health workers need to deliver mental health interventions through routine health care delivery systems, supervised by mental health specialists.

WHO (2008) notes that “by reorganizing the workforce in this way, task sharing presents a viable solution for improving health care coverage by making more efficient use of the human resources already available and by quickly increasing capacity while training and retention programmes are expanded”. (See http://www.who.int/mediacentre/events/meetings/task_shifting/en/index.html)

AFrica Focus on Intervention Research for Mental Health (AFFIRM) evaluated task sharing through the use of Community Health Workers in South Africa, and Primary Health Care workers in Ethiopia. In South Africa the focus is on pregnant women who are depressed, and in Ethiopia the focus is on people with severe mental disorders. This research and capacity development hub was established in 6 countries: Ethiopia, Ghana, Malawi, South Africa, Uganda and Zimbabwe.

AFFIRM aimed to investigate cost effective interventions for mental health disorders, through task-sharing by Community Health Workers in South Africa, and Primary Health Care workers in Ethiopia.

AFFIRM was led from the University of Cape Town, and funded by the National Institute of Mental Health (NIMH), USA. It included four components to address the specific aims:
1) Two randomised controlled trials on task shifting: one each in Ethiopia and South Africa;  2) A capacity building component primarily focused on the MPhil programme in Public Mental Health and a series of short courses, offered by UCT and Stellenbosch University; 3) A shared project across all NIMH hubs, examining scalability and replicability of task shifting interventions, and 4) Regular meetings to establish a network of collaborators in mental health research within sub-Saharan Africa, between AFFIRM, other hubs, the NIMH, and local researchers and mental health specialists.

The project’s specific aims included:

1.  Investigating strategies for narrowing the treatment gap for mental disorders in sub-Saharan Africa by:

  • Assessing the feasibility and acceptability of low cost task sharing interventions in Ethiopia and South Africa; and
  • Conducting randomised controlled trials (RCTs) of low cost task sharing interventions for severe mental disorders in Ethiopia and maternal depression in South Africa.

2.  Building individual and institutional capacity for intervention research in sub- Saharan Africa by:

  • Providing fellowship and mentorship programmes for candidates in Ethiopia, Ghana, Malawi, Uganda and Zimbabwe to develop capacity for mental health intervention research;
  • Offering short courses in mental health intervention research in sub-Saharan Africa; and
  • Providing supervision to Masters, PhD and post-doctoral students, who wish to base their research in either of the AFFIRM research sites in Ethiopia and South Africa.

3.  Establishing a network of collaboration between researchers, NGOs and government agencies that facilitates the
translation of research knowledge into policy and practice by:

  • Establishing knowledge exchange with Ministries of Health in all partner countries, regarding steps for evaluating and later scaling up task sharing interventions for mental health disorders; and
  • Producing communication materials, such as policy briefs and annual newsletters, on intervention research for mental health in sub-Saharan Africa, to be disseminated to partner Ministries of Health and NGOs.

4.  Collaborating with other NIMH hubs by:

  • Designing and executing shared research projects related to task sharing and narrowing the treatment gap; and
  • Pooling research knowledge from all hubs to contribute to global advocacy initiatives to narrow the treatment gap for mental disorders in Low and Middle Income Countries (LMIC)

AFFIRM is one of 4 hubs funded by the National Institute of Mental Health (part of the National Institutes of Health in the USA). These are:

AFFIRM: Sub-Saharan Africa (Ethiopia, Ghana, Malawi, South Africa, Uganda and Zimbabwe).

SHARE: the South Asian Hub for Advocacy, Research and Education on Mental Health (Bangladesh, India, Pakistan, Sri Lanka). See the SHARE Brochure for more information.

RedeAmericas: Network for Mental Health Research in the Americas (Argentina, Brazil, Chile, Colombia and USA). Click here for more information.

PaM-D: Partnerships for Mental Health Development in sub-Saharan Africa (Nigeria, Ghana, Kenya, Liberia and South Africa).

The first annual meeting of the hubs was held in Cape Town from 8 – 11 August 2012 (participants shown in the photo below), and the second one in Santiago, Chile, from 4-7 September 2013. The meetings provided a good forum for sharing ideas and developing networks.

AFFIRM Partners

Principal Investigators

Crick Lund, University of Cape Town

Atalay Alem, Addis Ababa University

Ezra Susser, Columbia University

Ethiopia

Charlotte Hanlon, Addis Ababa University

Principal Investigator: Ethiopian Trial

Abebaw Fekadu, Addis Ababa University

Girmay Medhin, Addis Ababa University

Teshome Shibre, Addis Ababa University

Ghana

Angela Ofori-Atta

Frank Nyanator, Health Services

Peter Yaro, Basic Needs

Malawi

Chiwoza Bandawe

Jen Ahrens

South Africa

Margie Schneider, UCT

Songelwa Mobo, UCT

Thandi Davies, UCT

Memory Nyatsanza, UCT

Simone Honikman, UCT

Inge Petersen, UKZN

Arvin Bhana, UKZN

John Joska, UCT

Dan Stein, UCT

Landon Myer, UCT

Leslie Swartz, SU

Ashraf Kagee, SU

Mark Tomlinson, SU

Jonathan Burns, UKZN

Melvyn Freeman, Department of Health

Sifiso Phakhati, Department of Health

Uganda

Seggane Musisi, Makerere University

Fred Kigozi, Makerere University

Tina Ntulo, Basic Needs

United Kingdom

Graham Thornicroft, King’s College London

Martin Prince, King’s College London

Melanie Abas, King’s College London

United States

Ezra Susser, Columbia University

Judy Bass, Johns Hopkins University

Paul Bolton, Johns Hopkins University

Larry Wissow, Johns Hopkins University

Zimbabwe

Frances Cowan

Dixon Chibanda

AFFIRM Partner Institutions

 

Alan J Flisher Centre for Public Mental Health
http://www.cpmh.org.za/

 

The Perinatal Mental Health Project
http://www.pmhp.za.org/

Prime

 

Programme for Improving Mental Health Care (PRIME)

http://www.prime.uct.ac.za/

 

Centre for Global Mental Health, King’s College London

http://www.centreforglobalmentalhealth.org/

 

Mailman School of Public Health, Columbia University, New York

http://www.mailman.columbia.edu/

 

Bloomberg School of Public Health, Johns Hopkins University, Baltimore

http://www.jhsph.edu/

 

Philani Child Health and Nutrition Project

http://www.philani.org.za/

 

The Parent Centre

https://theparentcentre.org.za/htt

CMH

 

Cape Mental Health

http://www.capementalhealth.co.za/

Re-engineered Primary Health Care for South Africa

PDF Slideshow

AFFIRM Capacity Building

MPhil Group of 2014
MPhil group & supervisors of 2014

The capacity building component aimed to build individual and institutional capacity for intervention research in mental health, in sub-Saharan Africa. This was addressed in part through the MPhil programme on Public Mental Health at UCT/Stellenbosch University, which sponsored 5 MPhil students from each of the 5 African countries other than South Africa. Other strategies include support for PhD students linked to the trials or shared projects, and short courses covering topics such as RCTs and policy making and planning for mental health.

2012 saw the first intake of AFFIRM fellows onto the MPhil in Public Mental Health, run jointly by UCT and Stellenbosch University (SU). 11 students were accepted onto the course in 2012 (pictured in the photo below), and five were sponsored by AFFIRM for one year. The students attended a residential two week course run jointly by the two universities in January 2012 and then returned home to continue their data collection and dissertations. They worked under the guidance of their supervisors based at UCT or SU. The students were very positive about the residential course but felt that the time was too short.

MPhil Group & Supervisors of 2013
MPhil group & supervisors of 2013

In January 2013 the second residential course was held at UCT and SU, and it was extended to three weeks. Five fellows from the five AFFIRM countries attended the course (pictured below) and all appreciated and enjoyed their time. They are all now in different stages of research and dissertation writing. An increased effort has been made to find more academic and supervisorial support for the students once they are back in their home countries.

MPhil group & supervisors of 2012
MPhil group & supervisors of 2012

In 2014 we accepted eight students to the course; five of whom were funded by AFFIRM and three were self-funded (see photo below). At the beginning of 2014 we also employed an MPhil coordinator to manage and coordinate the course, and assist the students throughout the year. Dr Katherine Sorsdahl has been in the UCT psychiatry department since 2006, and we welcome her to the project.

In addition to the institutional support provided by the CPMH, students are also supported by institutional partners such as Columbia University, King’s College, London and Johns Hopkins University, partners working as part of AFFIRM. In 2015, five more fellows were awarded the scholarship, and three students self funded themselves. Dr Sorsdahl has proved to be of very valuable assistance in supporting the students and improving the delivery of the programme.

AFFIRM Research

The research component comprises two randomised control trials (RCTs), one each in Cape Town, South Africa, and the Butajira district, Ethiopia.

THE SOUTH AFRICAN TRIAL IN KHAYELITSHA, CAPE TOWN – URBAN AREA

Principal Investigator: Crick Lund
High rates of antenatal and postnatal depression have been reported in Khayelitsha, and maternal depression has been shown to negatively impact the mother and her baby’s health. Our group is testing the efficacy of a counselling intervention for maternal depression in Khayelitsha in the form of a randomized controlled trial (RCT). What is special about this trial is that community health workers (CHWs) will be trained to deliver the intervention, as part of a task sharing strategy in primary health care.

With support from senior management in the Western Cape Government Department of Health, we are working with colleagues in the Michael Mapongwana Midwife Obstetric Unit and Site B Midwife Obstetric Unit.

PHASE 1
The first phase of this five year study involved formative research to establish the feasibility and acceptability of the intervention. Pregnant women and mothers of young babies were interviewed to discover issues that would affect the research and counselling intervention. Women were also interviewed about their perceptions and descriptions of depression, and its various causes and symptoms.

Also included in the formative phase was the development of a ‘Functional Assessment Instrument’, which aims to assess in what way depression specifically affects pregnant women and mothers of young infants in Khayelitsha. This is guided by collaborators from Johns Hopkins University.

PHASE 2
Official recruitment for the trial began in October 2013. This phase involves enrolling approximately 420 women into the RCT. As part of the RCT, the women will be randomly allocated to either receive the counselling intervention (6-8 sessions of a structured evidence-based programme delivered either in the clinic or at home by the CHWs), or receive enhanced usual care, which will comprise a monthly structured phone call from a CHW unassociated with the counselling CHWs.
Due to a slower than anticipated recruitment rate at Michael Mapongwana MOU, in January 2014 we included a second location for recruitment – Site B Community Centre MOU. The characteristics of the clinics and the women attending them are very similar, and recruitment increased, with the employment of two more field workers too. Recruitment was completed in October 2014, and the field workers are now concentrating on the follow up assessments, which occur at 1 month before birth, 3 months and 12 months after birth.

PHASE 3
The third phase will involve conducting qualitative interviews with some of the participants and the counsellors in order to ascertain the successes and challenges of the intervention.

One of the major questions we seek to answer through the research is whether community health workers can effectively deliver counselling interventions, as this may inform their role in delivering mental health services. This vision is part of the national primary health care revitalization programme, where ward agents or CHWs are expected to play a major preventive and promotive role.

THE ETHIOPIAN TRIAL IN BUTAJIRA, GURAGE ZONE – RURAL AREA

Principal Investigator: Charlotte Hanlon
The Ethiopian trial focuses on task sharing care of stabilised persons with severe mental disorders with primary health care workers (PHWs). The participants are already diagnosed with severe mental disorders and have been receiving care from psychiatric nurses at Butajira hospital. These participants will be randomised into intervention and comparison groups, with the intervention group being those whose mental health management or care plan is transferred to the primary health care level and managed by primary health care workers. The comparison group will continue receiving hospital based mental health care. The aim is to determine whether the transfer to the primary health care level is as effective and not inferior to the management by psychiatric nurses.

The formative phase explored a range of issues to be addressed in the main trial, such as how potential participants understand randomisation, and how well the intervention will be accepted given the history of receiving the hospital based services. The complexity of these issues has required the formative phase to be expanded to include discussions with relevant stakeholders on issues such as randomisation.

As with the South African trial, the Ethiopia team is also developing and adapting outcome measures for the main RCT. This will create an indigenous scale to measure functional impairment and recovery in persons with severe mental disorders in the Butajira District. In addition, a measure of patient satisfaction with services is being adapted for the Ethiopian context. These culturally appropriate measures will be used primarily as secondary outcome measures, but will also provide important insights into the functional status or people with mental disorders. They will be an important contribution from the AFFIRM project, with potential application in both clinical and research settings.

AFFIRM Publication List

2019

Lund, Crick; Schneider, Marguerite; Garman, Emily C; Davies, Thandi; Munodawafa, Memory; Honikman, Simone; Bhana, Arvin; Bass, Judith; Bolton, Paul; Dewey, Michael; Joska, John; Kagee, Ashraf; Myer, Landon; Petersen, Inge; Prince, Martin; Stein, Dan J; Tabana, Hanani; Thornicroft, Graham; Tomlinson, Mark; Hanlon, Charlotte; Alem, Atalay; Susser, Ezra

Task-sharing of psychological treatment for antenatal depression in Khayelitsha, South Africa: Effects on antenatal and postnatal outcomes in an individual randomised controlled trial Journal Article

Behaviour Research and Therapy, (September), 2019, ISSN: 1873622X.

Abstract | Links | BibTeX

Davies, Thandi; Garman, Emily C; Lund, Crick; Schneider, Marguerite

Adaptation and validation of a structured version of the Hamilton Depression Rating Scale for use by non-clinicians in South Africa (AFFIRM-HDRS) Journal Article

Journal of Evaluation in Clinical Practice, (November), pp. 1–11, 2019, ISSN: 13652753.

Abstract | Links | BibTeX

Garman, Emily C; Schneider, Marguerite; Lund, Crick

Perinatal depressive symptoms among low-income South African women at risk of depression: Trajectories and predictors Journal Article

BMC Pregnancy and Childbirth, 19 (1), pp. 1–11, 2019, ISSN: 14712393.

Abstract | Links | BibTeX

Garman, Emily C; Cois, Annibale; Schneider, Marguerite; Lund, Crick

Association between perinatal depressive symptoms and suicidal risk among low-income South African women: a longitudinal study Journal Article

Social Psychiatry and Psychiatric Epidemiology, 54 (10), pp. 1219–1230, 2019, ISSN: 14339285.

Abstract | Links | BibTeX

Da Silva, Andrea Tenório Correia ; Hanlon, Charlotte; Susser, Ezra; Rojas, Graciela; Claro, Heloísa Garcia; Quayle, Julieta; Habtamu, Kassahun; Burrone, María Soledad; Cavalcanti, Maria Tavares; Sharma, Mona; Schneider, Marguerite; Adhikari, Ramesh Prasad; Van De Water, Tanya ; Mohammed, Yasmin; ñ, Anna Ordó E; Seedat, Soraya

Enhancing mental health research capacity: Emerging voices from the National Institute of Mental Health (NIMH) global hubs Journal Article

International Journal of Mental Health Systems, 13 (1), pp. 1–9, 2019, ISSN: 17524458.

Abstract | Links | BibTeX

2018

Schneider, M; Baron, E; Davies, T; Munodawafa, M; Lund, C

Patterns of intimate partner violence among perinatal women with depression symptoms in Khayelitsha, South Africa: a longitudinal analysis Journal Article

Global Mental Health, 5 , 2018, ISSN: 2054-4251.

Abstract | Links | BibTeX

Kpobi, Lily; Swartz, Leslie; Ofori-Atta, Angela L

Challenges in the use of the mental health information system in a resource-limited setting: Lessons from Ghana Journal Article

BMC Health Services Research, 18 (1), pp. 1–8, 2018, ISSN: 14726963.

Abstract | Links | BibTeX

Habtamu, Kassahun; Alem, Atalay; Medhin, Girmay; Fekadu, Abebaw; Hanlon, Charlotte

Functional impairment among people with severe and enduring mental disorder in rural Ethiopia: a cross-sectional study Journal Article

Social Psychiatry and Psychiatric Epidemiology, 53 (8), pp. 803–814, 2018, ISSN: 09337954.

Abstract | Links | BibTeX

2017

Davies, T; Lund, C

Integrating mental health care into primary care systems in low- and middle-income countries: lessons from PRIME and AFFIRM Journal Article

Global Mental Health, 4 , 2017, ISSN: 2054-4251.

Abstract | Links | BibTeX

Mayston, Rosie; Habtamu, Kassahun; Medhin, Girmay; Alem, Atalay; Fekadu, Abebaw; Habtamu, Alehegn; Prince, Martin; Hanlon, Charlotte

Developing a measure of mental health service satisfaction for use in low income countries: a mixed methods study Journal Article

BMC Health Services Research, 17 (1), pp. 1–13, 2017, ISSN: 14726963.

Abstract | Links | BibTeX

Munodawafa, Memory; Lund, Crick; Schneider, Marguerite

A process evaluation exploring the lay counsellor experience of delivering a task shared psycho-social intervention for perinatal depression in Khayelitsha, South Africa Journal Article

BMC Psychiatry, 17 (1), pp. 1–12, 2017, ISSN: 1471244X.

Abstract | Links | BibTeX

Baron, Emily; Bass, Judith; Murray, Sarah M; Schneider, Marguerite; Lund, Crick

A systematic review of growth curve mixture modelling literature investigating trajectories of perinatal depressive symptoms and associated risk factors Journal Article

Journal of Affective Disorders, 223 (February), pp. 194–208, 2017, ISSN: 15732517.

Abstract | Links | BibTeX

Habtamu, Kassahun; Alem, Atalay; Medhin, Girmay; Fekadu, Abebaw; Dewey, Michael; Prince, Martin; Hanlon, Charlotte

Validation of the World Health Organization Disability Assessment Schedule in people with severe mental disorders in rural Ethiopia Journal Article

Health and Quality of Life Outcomes, 15 (1), pp. 1–11, 2017, ISSN: 14777525.

Abstract | Links | BibTeX

2016

Davies, Thandi; Schneider, Marguerite; Nyatsanza, Memory; Lund, Crick

"the sun has set even though it is morning": Experiences and explanations of perinatal depression in an urban township, Cape Town Journal Article

Transcultural Psychiatry, 53 (3), pp. 286–312, 2016, ISSN: 14617471.

Abstract | Links | BibTeX

Hanlon, Charlotte; Alem, Atalay; Medhin, Girmay; Shibre, Teshome; Ejigu, Dawit A; Negussie, Hanna; Dewey, Michael; Wissow, Lawrence; Prince, Martin; Susser, Ezra; Lund, Crick; Fekadu, Abebaw

Task sharing for the care of severe mental disorders in a low-income country (TaSCS): Study protocol for a randomised, controlled, non-inferiority trial Journal Article

Trials, 17 (1), pp. 1–14, 2016, ISSN: 17456215.

Abstract | Links | BibTeX

Nyatsanza, Memory; Schneider, Marguerite; Davies, Thandi; Lund, Crick

Filling the treatment gap: Developing a task sharing counselling intervention for perinatal depression in Khayelitsha, South Africa Journal Article

BMC Psychiatry, 16 (1), pp. 1–12, 2016, ISSN: 1471244X.

Abstract | Links | BibTeX

Marimbe, Bazondlile D; Cowan, Frances; Kajawu, Lazarus; Muchirahondo, Florence; Lund, Crick

Perceived burden of care and reported coping strategies and needs for family caregivers of people with mental disorders in Zimbabwe Journal Article

African Journal of Disability, 5 (1), pp. 1–9, 2016, ISSN: 2223-9170.

Abstract | Links | BibTeX

Schneider, M; van de Water, T; Araya, R; Bonini, B B; Pilowsky, D J; Pratt, C; Price, L; Rojas, G; Seedat, S; Sharma, M; Susser, E

Monitoring and evaluating capacity building activities in low and middle income countries: challenges and opportunities Journal Article

Global Mental Health, 3 , 2016, ISSN: 2054-4251.

Abstract | Links | BibTeX

Schneider, M; Sorsdahl, K; Mayston, R; Ahrens, J; Chibanda, D; Fekadu, A; Hanlon, C; Holzer, S; Musisi, S; Ofori-Atta, A; Thornicroft, G; Prince, M; Alem, A; Susser, E; Lund, C

Developing mental health research in sub-Saharan Africa: capacity building in the AFFIRM project Journal Article

Global Mental Health, 3 , 2016, ISSN: 2054-4251.

Abstract | Links | BibTeX

Pilowsky, Daniel J; Rojas, Graciela; Price, Leshawndra N; Appiah-Poku, John; Razzaque, Bushra; Sharma, Mona; Schneider, Marguerite; Seedat, Soraya; Bonini, Bárbara B; Gureje, Oye; Kola, Lola; Lund, Crick; Sorsdahl, Katherine; Araya, Ricardo; Menezes, Paulo R

Building research capacity across and within low- and middle-income countries: The collaborative hubs for international research on mental health Journal Article

Academic Psychiatry, 40 (4), pp. 686–691, 2016, ISSN: 15457230.

Links | BibTeX

Habtamu, Kassahun; Alem, Atalay; Medhin, Girmay; Fekadu, Abebaw; Prince, Martin; Hanlon, Charlotte

Development and validation of a contextual measure of functioning for people living with severe mental disorders in rural Africa Journal Article

BMC Psychiatry, 16 (1), pp. 1–13, 2016, ISSN: 1471244X.

Abstract | Links | BibTeX

2015

Schneider, Marguerite; Baron, Emily; Davies, Thandi; Bass, Judith; Lund, Crick

Making assessment locally relevant: measuring functioning for maternal depression in Khayelitsha, Cape Town Journal Article

Social Psychiatry and Psychiatric Epidemiology, 50 (5), pp. 797–806, 2015, ISSN: 09337954.

Abstract | Links | BibTeX

Lund, C; Alem, A; Schneider, M; Hanlon, C; Ahrens, J; Bandawe, C; Bass, J; Bhana, A; Burns, J; Chibanda, D; Cowan, F; Davies, T; Dewey, M; Fekadu, A; Freeman, M; Honikman, S; Joska, J; Kagee, A; Mayston, R; Medhin, G; Musisi, S; Myer, L; Ntulo, T; Nyatsanza, M; Ofori-Atta, A; Petersen, I; Phakathi, S; Prince, M; Shibre, T; Stein, D J; Swartz, L; Thornicroft, G; Tomlinson, M; Wissow, L; Susser, E

Generating evidence to narrow the treatment gap for mental disorders in sub-Saharan Africa: Rationale, overview and methods of AFFIRM Journal Article

Epidemiology and Psychiatric Sciences, 24 (3), pp. 233–240, 2015, ISSN: 20457979.

Abstract | Links | BibTeX

Habtamu, Kassahun; Alem, Atalay; Hanlon, Charlotte

Conceptualizing and contextualizing functioning in people with severe mental disorders in rural Ethiopia: A qualitative study Journal Article

BMC Psychiatry, 15 (1), pp. 1–13, 2015, ISSN: 1471244X.

Abstract | Links | BibTeX

2014

Lund, Crick; Schneider, Marguerite; Davies, Thandi; Nyatsanza, Memory; Honikman, Simone; Bhana, Arvin; Bass, Judith; Bolton, Paul; Dewey, Michael; Joska, John; Kagee, Ashraf; Myer, Landon; Petersen, Inge; Prince, Martin; Stein, Dan J; Thornicroft, Graham; Tomlinson, Mark; Alem, Atalay; Susser, Ezra

Task sharing of a psychological intervention for maternal depression in Khayelitsha, South Africa: Study protocol for a randomized controlled trial Journal Article

Trials, 15 (1), pp. 1–11, 2014, ISSN: 17456215.

Abstract | Links | BibTeX

Udedi, Michael; Swartz, Leslie; Stewart, Robert C; Kauye, Felix

Health service utilization by patients with common mental disorder identified by the Self-Reporting Questionnaire in a primary care setting in Zomba, Malawi: A descriptive study Journal Article

International Journal of Social Psychiatry, 60 (5), pp. 454–461, 2014, ISSN: 17412854.

Abstract | Links | BibTeX

Contact Us

For any inquiries, please contact the primary investigator, Prof Crick Lund at crick.lund[at]uct.ac.za.